The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice

OBJECTIVES: To study the effects of the selective TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), on fracture healing in mice and on an osteoprogenitor cell line, Kusa4b10, in vitro. METHODS: Mice received unilateral closed mid-shaft tibial fractures and treated for two weeks with vehicle or 5 mg/kg/d...

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Detalles Bibliográficos
Autores principales: Johnstone, Maddison R., Brady, Rhys D., Church, Jarrod E., Orr, David, McDonald, Stuart J., Grills, Brian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Musculoskeletal and Neuronal Interactions 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185262/
https://www.ncbi.nlm.nih.gov/pubmed/34059571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185262/
https://www.ncbi.nlm.nih.gov/pubmed/34059571

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