Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids

Human embryonic stem cells cultured in 2D micropatterns with BMP4 differentiate into a radial arrangement of germ layers and extraembryonic cells. Single-cell transcriptomes demonstrate generation of cell types transcriptionally similar to their in vivo counterparts in Carnegie stage 7 human gastrul...

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Detalles Bibliográficos
Autores principales: Minn, Kyaw Thu, Dietmann, Sabine, Waye, Sarah E., Morris, Samantha A., Solnica-Krezel, Lilianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185470/
https://www.ncbi.nlm.nih.gov/pubmed/33891870
http://dx.doi.org/10.1016/j.stemcr.2021.03.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185470/
https://www.ncbi.nlm.nih.gov/pubmed/33891870
http://dx.doi.org/10.1016/j.stemcr.2021.03.031

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