Cargando…

Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids

Human embryonic stem cells cultured in 2D micropatterns with BMP4 differentiate into a radial arrangement of germ layers and extraembryonic cells. Single-cell transcriptomes demonstrate generation of cell types transcriptionally similar to their in vivo counterparts in Carnegie stage 7 human gastrul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Minn, Kyaw Thu, Dietmann, Sabine, Waye, Sarah E., Morris, Samantha A., Solnica-Krezel, Lilianna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185470/ https://www.ncbi.nlm.nih.gov/pubmed/33891870 http://dx.doi.org/10.1016/j.stemcr.2021.03.031

Ejemplares similares

High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures
por: Minn, Kyaw Thu, et al.
Publicado: (2020)

Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation
por: Liu, Yinzi, et al.
Publicado: (2017)

A gastruloid model of the interaction between embryonic and extra-embryonic cell types
por: Bérenger-Currias, Noémie MLP, et al.
Publicado: (2022)

Imaging early embryonic calcium activity with GCaMP6s transgenic zebrafish
por: Chen, Jiakun, et al.
Publicado: (2017)

Nodal and planar cell polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements
por: Williams, Margot LK, et al.
Publicado: (2020)

Dissecting cell identity via network inference and in silico gene perturbation
por: Kamimoto, Kenji, et al.
Publicado: (2023)

Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution
por: Rossi, Giuliana, et al.
Publicado: (2022)

Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes
por: Williams, Margot L. K., et al.
Publicado: (2018)

YAP1 regulates the self-organized fate patterning of hESC-derived gastruloids
por: Stronati, Eleonora, et al.
Publicado: (2022)

Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin
por: Kim, Seok-Hyung, et al.
Publicado: (2011)

Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation
por: Yin, Chunyue, et al.
Publicado: (2008)

Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors
por: Malhotra, Divyanshu, et al.
Publicado: (2018)

Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids
por: Turner, David A., et al.
Publicado: (2017)

Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory
por: Kinoshita, Masaki, et al.
Publicado: (2021)

Multimodal characterization of murine gastruloid development
por: Suppinger, Simon, et al.
Publicado: (2023)

Chemokine GPCR Signaling Inhibits β-Catenin during Zebrafish Axis Formation
por: Wu, Shu-Yu, et al.
Publicado: (2012)

Essential roles of Gα(12/13) signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
por: Lin, Fang, et al.
Publicado: (2005)

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids
por: Chhabra, Sapna, et al.
Publicado: (2019)

Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites
por: Li, Nan, et al.
Publicado: (2008)

Gastruloid Development Competence Discriminates Different States of Pluripotency
por: Cermola, Federica, et al.
Publicado: (2021)

A combined human gastruloid model of cardiogenesis and neurogenesis
por: Olmsted, Zachary T., et al.
Publicado: (2022)

Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids
por: Hashmi, Ali, et al.
Publicado: (2022)

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning
por: Morgani, Sophie M, et al.
Publicado: (2018)

Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids
por: Cermola, Federica, et al.
Publicado: (2022)

Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues
por: Cooke, Christopher B., et al.
Publicado: (2023)

Budesonide Analogues Preserve Stem Cell Pluripotency and Delay 3D Gastruloid Development
por: Amoroso, Filomena, et al.
Publicado: (2023)

Cardiac Organoids and Gastruloids to Study Physio-Pathological Heart Development
por: Jaconi, Marisa E., et al.
Publicado: (2021)

Generation of human elongating multi-lineage organized cardiac gastruloids
por: Olmsted, Zachary T., et al.
Publicado: (2022)

Recording morphogen signals reveals origins of gastruloid symmetry breaking
por: McNamara, Harold M., et al.
Publicado: (2023)

Enhanced Hemangioblast Generation and Improved Vascular Repair and Regeneration from Embryonic Stem Cells by Defined Transcription Factors
por: Liu, Fang, et al.
Publicado: (2013)

Sec24D-Dependent Transport of Extracellular Matrix Proteins Is Required for Zebrafish Skeletal Morphogenesis
por: Sarmah, Swapnalee, et al.
Publicado: (2010)

Discriminating the Independent Influence of Cell Adhesion and Spreading Area on Stem Cell Fate Determination Using Micropatterned Surfaces
por: Wang, Xinlong, et al.
Publicado: (2016)

A New Approach to Generate Gastruloids to Develop Anterior Neural Tissues
por: Girgin, Mehmet, et al.
Publicado: (2023)

Codon usage optimization in pluripotent embryonic stem cells
por: Bornelöv, Susanne, et al.
Publicado: (2019)

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
por: Yoney, Anna, et al.
Publicado: (2018)

Gastruloids generated without exogenous Wnt activation develop anterior neural tissues
por: Girgin, Mehmet U., et al.
Publicado: (2021)

Response to Nodal morphogen gradient is determined by the kinetics of target gene induction
por: Dubrulle, Julien, et al.
Publicado: (2015)

Micropatterning of cells reveals chiral morphogenesis
por: Wan, Leo Q, et al.
Publicado: (2013)

Modeling cell shape and dynamics on micropatterns
por: Albert, Philipp J., et al.
Publicado: (2016)

In vitro teratogenicity testing using a 3D, embryo-like gastruloid system
por: Mantziou, Veronika, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_omsoej01osbp4fdkq75dcdggmo