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Porcupine inhibitor LGK-974 inhibits Wnt/β-catenin signaling and modifies tumor-associated macrophages resulting in inhibition of the malignant behaviors of non-small cell lung cancer cells
Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment that are tightly associated with malignancies in human cancers, including lung cancer. LGK-974, a small molecular inhibitor of Wnt secretion, was reported to block Wnt/β-catenin signaling and exert anti-inflamm...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185506/ https://www.ncbi.nlm.nih.gov/pubmed/34080032 http://dx.doi.org/10.3892/mmr.2021.12189 |