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Porcupine inhibitor LGK-974 inhibits Wnt/β-catenin signaling and modifies tumor-associated macrophages resulting in inhibition of the malignant behaviors of non-small cell lung cancer cells

Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment that are tightly associated with malignancies in human cancers, including lung cancer. LGK-974, a small molecular inhibitor of Wnt secretion, was reported to block Wnt/β-catenin signaling and exert anti-inflamm...

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Detalles Bibliográficos
Autores principales:	Tang, Yang, Jiang, Maoyan, Chen, Anping, Qu, Wendong, Han, Xu, Zuo, Jiebin, Xu, Gang, Song, Yongxiang, Chen, Cheng, Ke, Xixian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185506/ https://www.ncbi.nlm.nih.gov/pubmed/34080032 http://dx.doi.org/10.3892/mmr.2021.12189

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