A Mendelian Randomization Approach Using 3-HMG-Coenzyme-A Reductase Gene Variation to Evaluate the Association of Statin-Induced Low-Density Lipoprotein Cholesterol Lowering With Noncardiovascular Disease Phenotypes

IMPORTANCE: Observational studies suggest that statins, which inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, may be associated with beneficial effects in many noncardiovascular diseases. OBJECTIVE: To construct a weighted HMG-CoA reductase (HMGCR) gene genetic risk score (GRS) us...

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Detalles Bibliográficos
Autores principales: Liu, Ge, Shi, Mingjian, Mosley, Jonathan D., Weng, Chunhua, Zhang, Yanfei, Lee, Ming Ta Michael, Jarvik, Gail P., Hakonarson, Hakon, Namjou-Khales, Bahram, Sleiman, Patrick, Luo, Yuan, Mentch, Frank, Denny, Joshua C., Linton, MacRae F., Wei, Wei-Qi, Stein, C. Michael, Feng, QiPing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185593/
https://www.ncbi.nlm.nih.gov/pubmed/34097045
http://dx.doi.org/10.1001/jamanetworkopen.2021.12820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185593/
https://www.ncbi.nlm.nih.gov/pubmed/34097045
http://dx.doi.org/10.1001/jamanetworkopen.2021.12820

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