Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain

Activated ezrin-radixin-moesin (ERM) proteins link the plasma membrane to the actin cytoskeleton to generate apical structures, including microvilli. Among many kinases implicated in ERM activation are the homologues LOK and SLK. CRISPR/Cas9 was used to knock out all ERM proteins or LOK/SLK in human...

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Detalles Bibliográficos
Autores principales: Zaman, Riasat, Lombardo, Andrew, Sauvanet, Cécile, Viswanatha, Raghuvir, Awad, Valerie, Bonomo, Locke Ezra-Ros, McDermitt, David, Bretscher, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185690/
https://www.ncbi.nlm.nih.gov/pubmed/33836044
http://dx.doi.org/10.1083/jcb.202007146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185690/
https://www.ncbi.nlm.nih.gov/pubmed/33836044
http://dx.doi.org/10.1083/jcb.202007146

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