An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques

An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. The methodology is based on prior coupling of an aspartate fluoromethyl ketone to a linker and mounting it onto resin-bound methylbenzhydrylamine hydrochloride. Subsequently, by utilising standard Fm...

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Detalles Bibliográficos
Autores principales: Joshi, Dhira, Milligan, Jennifer C., Zeisner, Theresa U., O'Reilly, Nicola, Diffley, John F. X., Papageorgiou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185805/
https://www.ncbi.nlm.nih.gov/pubmed/34178310
http://dx.doi.org/10.1039/d1ra03046a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185805/
https://www.ncbi.nlm.nih.gov/pubmed/34178310
http://dx.doi.org/10.1039/d1ra03046a

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