Cargando…

Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling

BACKGROUND: Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, we sought to investigate the function of activating transcription factor 3 (ATF3) n GC chemoresistance. METHODS: Expression of ATF3 was determined in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Dazhi, Wang, Chunxiao, Yu, Lei, Yu, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186082/ https://www.ncbi.nlm.nih.gov/pubmed/34098867 http://dx.doi.org/10.1186/s11658-021-00271-y

Ejemplares similares

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
por: Chen, D, et al.
Publicado: (2017)

Erastin/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway
por: Li, Yu, et al.
Publicado: (2020)

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis
por: Zhang, Qi, et al.
Publicado: (2022)

Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC
por: Du, Linna, et al.
Publicado: (2023)

AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway
por: Feng, Hao, et al.
Publicado: (2022)

A xCT role in tumour-associated ferroptosis shed light on novel therapeutic options
por: Criscuolo, Daniela, et al.
Publicado: (2022)

STEAP3 Affects Ferroptosis and Progression of Renal Cell Carcinoma Through the p53/xCT Pathway
por: Ye, Cheng Lin, et al.
Publicado: (2022)

Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway
por: Wang, Sheng-Fan, et al.
Publicado: (2016)

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
por: Fan, Z, et al.
Publicado: (2017)

xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers
por: Lee, Namgyu, et al.
Publicado: (2021)

Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression
por: He, Ying, et al.
Publicado: (2023)

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
por: Cahuzac, Kaitlyn M., et al.
Publicado: (2023)

Targeting NRF2 Sensitizes Esophageal Adenocarcinoma Cells to Cisplatin through Induction of Ferroptosis and Apoptosis
por: Ballout, Farah, et al.
Publicado: (2022)

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis
por: Sehm, Tina, et al.
Publicado: (2016)

xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
por: Sugiyama, Akiko, et al.
Publicado: (2020)

A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT(KO) Pancreatic Ductal Adenocarcinoma Cells
por: Meira, Willian, et al.
Publicado: (2021)

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
por: Koppula, Pranavi, et al.
Publicado: (2020)

Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT-dependent ferroptosis pathway
por: Zhang, Liyi, et al.
Publicado: (2022)

d-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione
por: Homma, Takujiro, et al.
Publicado: (2022)

Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo
por: Shin, Seung-Shick, et al.
Publicado: (2018)

The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia
por: La Rosa, Piergiorgio, et al.
Publicado: (2020)

The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis
por: Yan, Renhong, et al.
Publicado: (2022)

Exosomes Derived from Baicalin-Pretreated Mesenchymal Stem Cells Alleviate Hepatocyte Ferroptosis after Acute Liver Injury via the Keap1-NRF2 Pathway
por: Zhao, Shuxian, et al.
Publicado: (2022)

Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway
por: Ding, Jin, et al.
Publicado: (2023)

Growth differentiation factor 15 induces cisplatin resistance through upregulation of xCT expression and glutathione synthesis in gastric cancer
por: Wang, Sheng‐Fan, et al.
Publicado: (2023)

LTBP2 Knockdown Promotes Ferroptosis in Gastric Cancer Cells through p62-Keap1-Nrf2 Pathway
por: Wang, TingAn, et al.
Publicado: (2022)

Expression of xCT and activity of system x(c)(−) are regulated by NRF2 in human breast cancer cells in response to oxidative stress
por: Habib, Eric, et al.
Publicado: (2015)

Sulfasalazine Sensitizes Polyhematoporphyrin-Mediated Photodynamic Therapy in Cholangiocarcinoma by Targeting xCT
por: Zheng, Yan-Wen, et al.
Publicado: (2021)

Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis-Induced Acute Lung Injury through GSK3β/Keap1-Nrf2-GPX4 Pathway
por: Wang, Yu-Ming, et al.
Publicado: (2022)

ATP2B3 Inhibition Alleviates Erastin–Induced Ferroptosis in HT-22 Cells through the P62–KEAP1–NRF2–HO-1 Pathway
por: Guo, Shihui, et al.
Publicado: (2023)

Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2
por: Han, Yuying, et al.
Publicado: (2022)

Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway
por: Tang, Kezhong, et al.
Publicado: (2022)

Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury
por: Li, Xuan, et al.
Publicado: (2022)

FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
por: Emmanuel, Nsengiyumva, et al.
Publicado: (2022)

Molecular mechanism of paraquat-induced ferroptosis leading to pulmonary fibrosis mediated by Keap1/Nrf2 signaling pathway
por: Yang, Xiaoxia, et al.
Publicado: (2023)

WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury
por: Deng, Zebin, et al.
Publicado: (2023)

Scalp Acupuncture Protects Against Neuronal Ferroptosis by Activating The p62-Keap1-Nrf2 Pathway in Rat Models of Intracranial Haemorrhage
por: Li, Ming-Yue, et al.
Publicado: (2021)

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells
por: Chen, Wenkai, et al.
Publicado: (2023)

Role and Mechanism of Keap1/Nrf2 Signaling Pathway in the Regulation of Autophagy in Alleviating Pulmonary Fibrosis
por: Dong, Zhaoxing, et al.
Publicado: (2022)

xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation
por: Cai, Yi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kabcdlat0500of0otnnerrng44