The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar eff...

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Detalles Bibliográficos
Autores principales: Cai, Xingguang, Javor, Sacha, Gan, Bee Ha, Köhler, Thilo, Reymond, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186529/
https://www.ncbi.nlm.nih.gov/pubmed/33972964
http://dx.doi.org/10.1039/d1cc01838h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186529/
https://www.ncbi.nlm.nih.gov/pubmed/33972964
http://dx.doi.org/10.1039/d1cc01838h

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