The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar eff...

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Detalles Bibliográficos
Autores principales: Cai, Xingguang, Javor, Sacha, Gan, Bee Ha, Köhler, Thilo, Reymond, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186529/
https://www.ncbi.nlm.nih.gov/pubmed/33972964
http://dx.doi.org/10.1039/d1cc01838h
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author Cai, Xingguang
Javor, Sacha
Gan, Bee Ha
Köhler, Thilo
Reymond, Jean-Louis
author_facet Cai, Xingguang
Javor, Sacha
Gan, Bee Ha
Köhler, Thilo
Reymond, Jean-Louis
author_sort Cai, Xingguang
collection PubMed
description pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.
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spelling pubmed-81865292021-06-23 The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4 Cai, Xingguang Javor, Sacha Gan, Bee Ha Köhler, Thilo Reymond, Jean-Louis Chem Commun (Camb) Chemistry pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials. The Royal Society of Chemistry 2021-05-05 /pmc/articles/PMC8186529/ /pubmed/33972964 http://dx.doi.org/10.1039/d1cc01838h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Cai, Xingguang
Javor, Sacha
Gan, Bee Ha
Köhler, Thilo
Reymond, Jean-Louis
The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
title The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
title_full The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
title_fullStr The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
title_full_unstemmed The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
title_short The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
title_sort antibacterial activity of peptide dendrimers and polymyxin b increases sharply above ph 7.4
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186529/
https://www.ncbi.nlm.nih.gov/pubmed/33972964
http://dx.doi.org/10.1039/d1cc01838h
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