Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease

INTRODUCTION: As a key event leading to tubulointerstitial fibrosis in diabetic kidney disease (DKD), epithelial–mesenchymal transition (EMT) has drawn increasing attention from researchers. The antiaging protein Klotho attenuates renal fibrosis in part by inhibiting ERK1/2 signaling in DKD. Early g...

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Detalles Bibliográficos
Autores principales: Li, Yang, Xue, Meng, Hu, Fang, Jia, Yijie, Zheng, Zongji, Yang, Yanlin, Liu, Xiaolian, Yang, Yuelian, Wang, Yanjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Pathophysiology/Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186752/
https://www.ncbi.nlm.nih.gov/pubmed/34099438
http://dx.doi.org/10.1136/bmjdrc-2020-002038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186752/
https://www.ncbi.nlm.nih.gov/pubmed/34099438
http://dx.doi.org/10.1136/bmjdrc-2020-002038

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