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Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease
INTRODUCTION: As a key event leading to tubulointerstitial fibrosis in diabetic kidney disease (DKD), epithelial–mesenchymal transition (EMT) has drawn increasing attention from researchers. The antiaging protein Klotho attenuates renal fibrosis in part by inhibiting ERK1/2 signaling in DKD. Early g...
Autores principales: | Li, Yang, Xue, Meng, Hu, Fang, Jia, Yijie, Zheng, Zongji, Yang, Yanlin, Liu, Xiaolian, Yang, Yuelian, Wang, Yanjing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186752/ https://www.ncbi.nlm.nih.gov/pubmed/34099438 http://dx.doi.org/10.1136/bmjdrc-2020-002038 |
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