Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course

Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major impact on the prognostication and treatment of this disease. A hallmark of IGHV-mutation status is that it very rarely changes clonally over time. Nevertheless, targeted and deep DNA sequencing of IGHV-IGHD-IGHJ r...

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Detalles Bibliográficos
Autores principales: Bagnara, Davide, Tang, Catherine, Brown, Jennifer R., Kasar, Siddha, Fernandes, Stacey, Colombo, Monica, Vergani, Stefano, Mazzarello, Andrea N., Ghiotto, Fabio, Bruno, Silvia, Morabito, Fortunato, Rai, Kanti R., Kolitz, Jonathan E., Barrientos, Jacqueline C., Allen, Steven L., Fais, Franco, Scharff, Matthew D., MacCarthy, Thomas, Chiorazzi, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186829/
https://www.ncbi.nlm.nih.gov/pubmed/34113563
http://dx.doi.org/10.3389/fonc.2021.640731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186829/
https://www.ncbi.nlm.nih.gov/pubmed/34113563
http://dx.doi.org/10.3389/fonc.2021.640731

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