A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

Age-related changes to histone levels are seen in many species. However, it is unclear whether changes to histone expression could be exploited to ameliorate the effects of ageing in multicellular organisms. Here we show that inhibition of mTORC1 by the lifespan-extending drug rapamycin increases ex...

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Detalles Bibliográficos
Autores principales: Lu, Yu-Xuan, Regan, Jennifer C, Eßer, Jacqueline, Drews, Lisa F, Weinseis, Thomas, Stinn, Julia, Hahn, Oliver, Miller, Richard A, Grönke, Sebastian, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186904/
https://www.ncbi.nlm.nih.gov/pubmed/33988501
http://dx.doi.org/10.7554/eLife.62233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186904/
https://www.ncbi.nlm.nih.gov/pubmed/33988501
http://dx.doi.org/10.7554/eLife.62233

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