Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system

Prolonged hyperglycemia plays a major role in the progression of β-cell loss in diabetes mellitus. Here we report an insulin sensitizer thiazolidinedione Pioglitazone selectively preserves the beta cells against high glucose-induced dysfunction by activation of AMPK and Glutaminase 1 (GLS1) axis. AM...

Descripción completa

Detalles Bibliográficos
Autores principales: Karunakaran, Udayakumar, Elumalai, Suma, Moon, Jun Sung, Won, Kyu Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187239/
https://www.ncbi.nlm.nih.gov/pubmed/34107382
http://dx.doi.org/10.1016/j.redox.2021.102029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187239/
https://www.ncbi.nlm.nih.gov/pubmed/34107382
http://dx.doi.org/10.1016/j.redox.2021.102029

Ejemplares similares