A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells

p53, the major tumor suppressor, is frequently mutated in many cancers, and up to 84% of human melanomas harbor wild-type p53, which is considered to be an ideal target for melanoma therapy. Here, we evaluated the antitumor activity of a carbazole derivative, 9-ethyl-9H-carbazole-3-carbaldehyde (ECC...

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Detalles Bibliográficos
Autores principales: Wen, Jie, Chen, Wenqian, Zhao, Baoxiang, Xu, Qiuping, Liu, Chang, Zhang, Qun, Xie, Zhiwei, Yan, Yonggan, Guo, Jing, Huang, Jun, Miao, Junying, Wu, Xunwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187445/
https://www.ncbi.nlm.nih.gov/pubmed/34103468
http://dx.doi.org/10.1038/s41419-021-03867-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187445/
https://www.ncbi.nlm.nih.gov/pubmed/34103468
http://dx.doi.org/10.1038/s41419-021-03867-6

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