Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression

Cyclic-AMP (cAMP) exerts suppressive effects in the innate and adaptive immune system. The PD-1/PD-L1 immune checkpoint down-regulates T-cell activity. Here, we examined if these two immunosuppressive nodes intersect. Using normal and malignant lymphocytes from humans, and the phosphodiesterase 4b (...

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Detalles Bibliográficos
Autores principales: Sasi, Binu, Ethiraj, Purushoth, Myers, Jamie, Lin, An-Ping, Jiang, Shoulei, Qiu, Zhijun, Holder, Kenneth N., Aguiar, Ricardo C. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187478/
https://www.ncbi.nlm.nih.gov/pubmed/33299141
http://dx.doi.org/10.1038/s41375-020-01105-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187478/
https://www.ncbi.nlm.nih.gov/pubmed/33299141
http://dx.doi.org/10.1038/s41375-020-01105-0

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