Inactivation of Latent HIV-1 Proviral DNA Using Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Treatment and the Assessment of Off-Target Effects

Viral DNA integrated in host cells is a major barrier to completely curing HIV-1. However, genome editing using the recently developed technique of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has the potential to eradicate HIV-1. The present study aimed to use a lentivira...

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Detalles Bibliográficos
Autores principales: Xu, Yufan, Peng, Xiaorong, Zheng, Yanghao, Jin, Changzhong, Lu, Xiangyun, Han, Dating, Fu, Haijing, Chen, Chaoyu, Wu, Nanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187572/
https://www.ncbi.nlm.nih.gov/pubmed/34122355
http://dx.doi.org/10.3389/fmicb.2021.629153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187572/
https://www.ncbi.nlm.nih.gov/pubmed/34122355
http://dx.doi.org/10.3389/fmicb.2021.629153

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