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Inactivation of Latent HIV-1 Proviral DNA Using Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Treatment and the Assessment of Off-Target Effects
Viral DNA integrated in host cells is a major barrier to completely curing HIV-1. However, genome editing using the recently developed technique of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has the potential to eradicate HIV-1. The present study aimed to use a lentivira...
Autores principales: | Xu, Yufan, Peng, Xiaorong, Zheng, Yanghao, Jin, Changzhong, Lu, Xiangyun, Han, Dating, Fu, Haijing, Chen, Chaoyu, Wu, Nanping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187572/ https://www.ncbi.nlm.nih.gov/pubmed/34122355 http://dx.doi.org/10.3389/fmicb.2021.629153 |
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