Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice

Random errors in protein synthesis are prevalent and ubiquitous, yet their effect on organismal health has remained enigmatic for over five decades. Here, we studied whether mice carrying the ribosomal ambiguity (ram) mutation Rps2-A226Y, recently shown to increase the inborn error rate of mammalian...

Descripción completa

Detalles Bibliográficos
Autores principales: Moore, James, Akbergenov, Rashid, Nigri, Martina, Isnard-Petit, Patricia, Grimm, Amandine, Seebeck, Petra, Restelli, Lisa, Frank, Stephan, Eckert, Anne, Thiam, Kader, Wolfer, David P., Shcherbakov, Dimitri, Böttger, Erik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187632/
https://www.ncbi.nlm.nih.gov/pubmed/34103648
http://dx.doi.org/10.1038/s42003-021-02204-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187632/
https://www.ncbi.nlm.nih.gov/pubmed/34103648
http://dx.doi.org/10.1038/s42003-021-02204-z

Ejemplares similares