Extracellular mutation induces an allosteric effect across the membrane and hampers the activity of MRP1 (ABCC1)

Dynamic conformational changes play a major role in the function of proteins, including the ATP-Binding Cassette (ABC) transporters. Multidrug Resistance Protein 1 (MRP1) is an ABC exporter that protects cells from toxic molecules. Overexpression of MRP1 has been shown to confer Multidrug Resistance...

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Detalles Bibliográficos
Autores principales: Bin Kanner, Yuval, Ganoth, Assaf, Tsfadia, Yossi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187718/
https://www.ncbi.nlm.nih.gov/pubmed/34103599
http://dx.doi.org/10.1038/s41598-021-91461-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187718/
https://www.ncbi.nlm.nih.gov/pubmed/34103599
http://dx.doi.org/10.1038/s41598-021-91461-3

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