NOTCH1 Activation Negatively Impacts on Chronic Lymphocytic Leukemia Outcome and Is Not Correlated to the NOTCH1 and IGHV Mutational Status

NOTCH1 mutations and deregulated signal have been commonly found in chronic lymphocytic leukemia (CLL) patients. Whereas the impact of NOTCH1 mutations on clinical course of CLL has been widely studied, the prognostic role of NOTCH1 activation in CLL remains to be defined. Here, we analyzed the acti...

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Detalles Bibliográficos
Autores principales: Baldoni, Stefano, Del Papa, Beatrice, De Falco, Filomena, Dorillo, Erica, Sorrentino, Carlo, Rompietti, Chiara, Adamo, Francesco Maria, Nogarotto, Manuel, Cecchini, Debora, Mondani, Elena, Silva Barcelos, Estevao Carlos, Moretti, Lorenzo, Mameli, Maria Grazia, Fabi, Bianca, Sorcini, Daniele, Stella, Arianna, Giancola, Raffaella, Guardalupi, Francesco, Ulbar, Francesca, Plebani, Sara, Guarente, Valerio, Rosati, Emanuela, Di Nicola, Marta, Marchioni, Michele, Di Ianni, Mauro, Sportoletti, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187905/
https://www.ncbi.nlm.nih.gov/pubmed/34123837
http://dx.doi.org/10.3389/fonc.2021.668573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187905/
https://www.ncbi.nlm.nih.gov/pubmed/34123837
http://dx.doi.org/10.3389/fonc.2021.668573

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