Discovery of Potent EGFR Inhibitors With 6-Arylureido-4-anilinoquinazoline Derivatives

According to the classical pharmacophore fusion strategy, a series of 6-arylureido-4-anilinoquinazoline derivatives (Compounds 7a–t) were designed, synthesized, and biologically evaluated by the standard CCK-8 method and enzyme inhibition assay. Among the title compounds, Compounds 7a, 7c, 7d, 7f, 7...

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Detalles Bibliográficos
Autores principales: Li, Meng, Xue, Na, Liu, Xingang, Wang, Qiaoyun, Yan, Hongyi, Liu, Yifan, Wang, Lei, Shi, Xiaowei, Cao, Deying, Zhang, Kai, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187944/
https://www.ncbi.nlm.nih.gov/pubmed/34122069
http://dx.doi.org/10.3389/fphar.2021.647591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187944/
https://www.ncbi.nlm.nih.gov/pubmed/34122069
http://dx.doi.org/10.3389/fphar.2021.647591

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