Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways

Mitochondria regulate the immune response after dengue virus (DENV) infection. Microarray analysis of genes identified the upregulation of mitochondrial cytidine/uridine monophosphate kinase 2 (CMPK2) by DENV infection. We used small interfering RNA-mediated knockdown (KD) and CRISPR-Cas9 knockout (...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Jenn-Haung, Wu, De-Wei, Wu, Chien-Hsiang, Hung, Li-Feng, Huang, Chuan-Yueh, Ka, Shuk-Man, Chen, Ann, Chang, Zee-Fen, Ho, Ling-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188380/
https://www.ncbi.nlm.nih.gov/pubmed/34142025
http://dx.doi.org/10.1016/j.isci.2021.102498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188380/
https://www.ncbi.nlm.nih.gov/pubmed/34142025
http://dx.doi.org/10.1016/j.isci.2021.102498

Ejemplares similares