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Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways

Mitochondria regulate the immune response after dengue virus (DENV) infection. Microarray analysis of genes identified the upregulation of mitochondrial cytidine/uridine monophosphate kinase 2 (CMPK2) by DENV infection. We used small interfering RNA-mediated knockdown (KD) and CRISPR-Cas9 knockout (...

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Detalles Bibliográficos
Autores principales:	Lai, Jenn-Haung, Wu, De-Wei, Wu, Chien-Hsiang, Hung, Li-Feng, Huang, Chuan-Yueh, Ka, Shuk-Man, Chen, Ann, Chang, Zee-Fen, Ho, Ling-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188380/ https://www.ncbi.nlm.nih.gov/pubmed/34142025 http://dx.doi.org/10.1016/j.isci.2021.102498

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