Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway

Lipotoxicity plays an important role in the development of diabetic heart failure (HF). Canagliflozin (CAN), a marketed sodium-glucose co-transporter 2 inhibitor, has significantly beneficial effects on HF. In this study, we evaluated the protective effects and mechanism of CAN in the hearts of C57B...

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Detalles Bibliográficos
Autores principales: Sun, Pengbo, Wang, Yangyang, Ding, Yipei, Luo, Jingyi, Zhong, Jin, Xu, Naihan, Zhang, Yaou, Xie, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188479/
https://www.ncbi.nlm.nih.gov/pubmed/34142035
http://dx.doi.org/10.1016/j.isci.2021.102521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188479/
https://www.ncbi.nlm.nih.gov/pubmed/34142035
http://dx.doi.org/10.1016/j.isci.2021.102521

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