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Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway

Lipotoxicity plays an important role in the development of diabetic heart failure (HF). Canagliflozin (CAN), a marketed sodium-glucose co-transporter 2 inhibitor, has significantly beneficial effects on HF. In this study, we evaluated the protective effects and mechanism of CAN in the hearts of C57B...

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Detalles Bibliográficos
Autores principales:	Sun, Pengbo, Wang, Yangyang, Ding, Yipei, Luo, Jingyi, Zhong, Jin, Xu, Naihan, Zhang, Yaou, Xie, Weidong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188479/ https://www.ncbi.nlm.nih.gov/pubmed/34142035 http://dx.doi.org/10.1016/j.isci.2021.102521

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