Membrane destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR/Cas gene editing

Endosomal escape remains a fundamental barrier hindering advancement of nucleic acid therapeutics. Taking inspiration from natural phospholipids that comprise biological membranes, we report the combinatorial synthesis of multi-tailed ionizable phospholipids (iPhos) capable of delivering mRNA or mRN...

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Detalles Bibliográficos
Autores principales: Liu, Shuai, Cheng, Qiang, Wei, Tuo, Yu, Xueliang, Johnson, Lindsay T., Farbiak, Lukas, Siegwart, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188687/
https://www.ncbi.nlm.nih.gov/pubmed/33542471
http://dx.doi.org/10.1038/s41563-020-00886-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188687/
https://www.ncbi.nlm.nih.gov/pubmed/33542471
http://dx.doi.org/10.1038/s41563-020-00886-0

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