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Membrane destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR/Cas gene editing
Endosomal escape remains a fundamental barrier hindering advancement of nucleic acid therapeutics. Taking inspiration from natural phospholipids that comprise biological membranes, we report the combinatorial synthesis of multi-tailed ionizable phospholipids (iPhos) capable of delivering mRNA or mRN...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188687/ https://www.ncbi.nlm.nih.gov/pubmed/33542471 http://dx.doi.org/10.1038/s41563-020-00886-0 |