CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered key contributors to AD pathogenesis, their contribution in the combined presence of ATN...

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Detalles Bibliográficos
Autores principales: Lodder, Chritica, Scheyltjens, Isabelle, Stancu, Ilie Cosmin, Botella Lucena, Pablo, Gutiérrez de Ravé, Manuel, Vanherle, Sarah, Vanmierlo, Tim, Cremers, Niels, Vanrusselt, Hannah, Brône, Bert, Hanseeuw, Bernard, Octave, Jean-Noël, Bottelbergs, Astrid, Movahedi, Kiavash, Dewachter, Ilse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188790/
https://www.ncbi.nlm.nih.gov/pubmed/34103079
http://dx.doi.org/10.1186/s40478-021-01204-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188790/
https://www.ncbi.nlm.nih.gov/pubmed/34103079
http://dx.doi.org/10.1186/s40478-021-01204-8

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