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Decoding molnupiravir-induced mutagenesis in SARS-CoV-2
Molnupiravir, a prodrug of the nucleoside derivative β-D-N(4)-hydroxycytidine (NHC), is currently in clinical trials for COVID-19 therapy. However, the biochemical mechanisms involved in molnupiravir-induced mutagenesis had not been explored. In a recent study, Gordon et al. demonstrated that NHC ca...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188802/ https://www.ncbi.nlm.nih.gov/pubmed/34118236 http://dx.doi.org/10.1016/j.jbc.2021.100867 |