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Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

Somatodendritic dopamine (DA) release from midbrain DA neurons activates D2 autoreceptors on these cells to regulate their activity. However, the source of autoregulatory DA remains controversial. Here, we test the hypothesis that D2 autoreceptors on a given DA neuron in the substantia nigra pars co...

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Detalles Bibliográficos
Autores principales: Hikima, Takuya, Lee, Christian R., Witkovsky, Paul, Chesler, Julia, Ichtchenko, Konstantin, Rice, Margaret E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189326/
https://www.ncbi.nlm.nih.gov/pubmed/33826884
http://dx.doi.org/10.1016/j.celrep.2021.108951