A reaction-diffusion network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila

Dorsal-ventral patterning of the Drosophila embryo depends on the NFκB superfamily transcription factor Dorsal (Dl). Toll receptor activation signals for degradation of the IκB inhibitor Cactus (Cact), leading to a ventral-to-dorsal nuclear Dl gradient. Cact is critical for Dl nuclear import, as it...

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Detalles Bibliográficos
Autores principales: Barros, Claudio D. T., Cardoso, Maira A., Bisch, Paulo M., Araujo, Helena M., Lopes, Francisco J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189453/
https://www.ncbi.nlm.nih.gov/pubmed/34043616
http://dx.doi.org/10.1371/journal.pcbi.1009040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189453/
https://www.ncbi.nlm.nih.gov/pubmed/34043616
http://dx.doi.org/10.1371/journal.pcbi.1009040

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