Cargando…

TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2

Antiviral therapeutics are a front-line defense against virally induced diseases. Because viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in targeting the host proteins that the virus must co-opt to complete its replication cycle. However, a detailed unders...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trimarco, Joseph D., Heaton, Brook E., Chaparian, Ryan R., Burke, Kaitlyn N., Binder, Raquel A., Gray, Gregory C., Smith, Clare M., Menachery, Vineet D., Heaton, Nicholas S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189496/ https://www.ncbi.nlm.nih.gov/pubmed/34043740 http://dx.doi.org/10.1371/journal.ppat.1009599

Ejemplares similares

Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication
por: Sun, Limeng, et al.
Publicado: (2021)

A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice
por: Chaparian, Ryan R., et al.
Publicado: (2022)

Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity
por: Froggatt, Heather M., et al.
Publicado: (2021)

Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection
por: Trimarco, Joseph D., et al.
Publicado: (2022)

VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection
por: Ji, Mingming, et al.
Publicado: (2022)

In silico prediction of structure and function for a large family of transmembrane proteins that includes human Tmem41b
por: Mesdaghi, Shahram, et al.
Publicado: (2021)

Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication
por: Yaron, Tomer M., et al.
Publicado: (2022)

ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection
por: Zhu, Xinyu, et al.
Publicado: (2022)

Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation
por: Morita, Keigo, et al.
Publicado: (2018)

TMEM41B is a pan-flavivirus host factor
por: Hoffmann, H.-Heinrich, et al.
Publicado: (2020)

TMEM41B Is a Pan-flavivirus Host Factor
por: Hoffmann, H.-Heinrich, et al.
Publicado: (2021)

In vitro and in vivo assay of the ER lipid scramblase TMEM41B
por: Wu, Lingzhi, et al.
Publicado: (2022)

Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CL(pro) Reporter Assay
por: Froggatt, Heather M., et al.
Publicado: (2020)

Coronavirus 2′-O-methyltransferase: A promising therapeutic target
por: Schindewolf, Craig, et al.
Publicado: (2023)

Return of the Coronavirus: 2019-nCoV
por: Gralinski, Lisa E., et al.
Publicado: (2020)

Impact of Four Ovine TMEM154 Haplotypes on Ewes during Multiyear Lentivirus Exposure
por: Freking, Brad A., et al.
Publicado: (2022)

TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine
por: Li, Yang Emma, et al.
Publicado: (2021)

Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs
por: Harding, Alfred T., et al.
Publicado: (2017)

Genetic Testing for TMEM154 Mutations Associated with Lentivirus Susceptibility in Sheep
por: Heaton, Michael P., et al.
Publicado: (2013)

Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
por: Menachery, Vineet D., et al.
Publicado: (2014)

Replication and meta-analysis of TMEM132D gene variants in panic disorder
por: Erhardt, A, et al.
Publicado: (2012)

Jumping species—a mechanism for coronavirus persistence and survival
por: Menachery, Vineet D, et al.
Publicado: (2017)

Small ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes
por: Sider, Lucia H, et al.
Publicado: (2013)

Reduced Lentivirus Susceptibility in Sheep with TMEM154 Mutations
por: Heaton, Michael P., et al.
Publicado: (2012)

TMEM41A overexpression correlates with poor prognosis and immune alterations in patients with endometrial carcinoma
por: Shi, Ke, et al.
Publicado: (2023)

Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses
por: Johnson, Bryan A., et al.
Publicado: (2018)

Influenza viruses that require 10 genomic segments as antiviral therapeutics
por: Harding, Alfred T., et al.
Publicado: (2019)

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection
por: Yousefi, Meisam, et al.
Publicado: (2022)

TMEM218 dysfunction causes ciliopathies, including Joubert and Meckel syndromes
por: Van De Weghe, Julie C., et al.
Publicado: (2020)

SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)
por: van Doremalen, Neeltje, et al.
Publicado: (2018)

DNA mismatch repair controls the host innate response and cell fate after influenza virus infection
por: Chambers, Benjamin S., et al.
Publicado: (2019)

Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4(Δ)53
por: Clawson, Michael L, et al.
Publicado: (2015)

Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses
por: Prasanth, K. Reddisiva, et al.
Publicado: (2020)

Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses
por: Prasanth, K. Reddisiva, et al.
Publicado: (2020)

Epithelial Chloride Transport by CFTR Requires TMEM16A
por: Benedetto, Roberta, et al.
Publicado: (2017)

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor
por: Shoemaker, Christopher J., et al.
Publicado: (2019)

“VTT”-Domain Proteins VMP1 and TMEM41B Function in Lipid Homeostasis Globally and Locally as ER Scramblases
por: Reinisch, Karin M., et al.
Publicado: (2021)

MERS Vaccine Candidate Offers Promise, but Questions Remain
por: Menachery, Vineet D.
Publicado: (2015)

TMEM41B, a novel ER phospholipid scramblase mediating systemic lipid metabolism: A novel ER phospholipid scramblase
por: Hu, Haoliang, et al.
Publicado: (2022)

TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis
por: Shambharkar, Prashant B., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_601bk9vi1proiua5ad6s8np79e