ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease

The rho-associated coiled-coil–containing protein kinase-2 (ROCK2) signaling pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways. Selective ROCK2 inhibition with belumosudil (KD025) may offer a novel approach to the management of chronic graft-versus-host disease...

Descripción completa

Detalles Bibliográficos
Autores principales: Jagasia, Madan, Lazaryan, Aleksandr, Bachier, Carlos R., Salhotra, Amandeep, Weisdorf, Daniel J., Zoghi, Behyar, Essell, James, Green, Laurie, Schueller, Olivier, Patel, Jeegar, Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Yang, Zhongming, Eiznhamer, David, Aggarwal, Sanjay K., Blazar, Bruce R., Lee, Stephanie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2021
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189612/
https://www.ncbi.nlm.nih.gov/pubmed/33877856
http://dx.doi.org/10.1200/JCO.20.02754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189612/
https://www.ncbi.nlm.nih.gov/pubmed/33877856
http://dx.doi.org/10.1200/JCO.20.02754

Ejemplares similares