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ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease

The rho-associated coiled-coil–containing protein kinase-2 (ROCK2) signaling pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways. Selective ROCK2 inhibition with belumosudil (KD025) may offer a novel approach to the management of chronic graft-versus-host disease...

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Detalles Bibliográficos
Autores principales:	Jagasia, Madan, Lazaryan, Aleksandr, Bachier, Carlos R., Salhotra, Amandeep, Weisdorf, Daniel J., Zoghi, Behyar, Essell, James, Green, Laurie, Schueller, Olivier, Patel, Jeegar, Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Yang, Zhongming, Eiznhamer, David, Aggarwal, Sanjay K., Blazar, Bruce R., Lee, Stephanie J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2021
Materias:	ORIGINAL REPORTS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189612/ https://www.ncbi.nlm.nih.gov/pubmed/33877856 http://dx.doi.org/10.1200/JCO.20.02754

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