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Inferring TF activities and activity regulators from gene expression data with constraints from TF perturbation data
MOTIVATION: The activity of a transcription factor (TF) in a sample of cells is the extent to which it is exerting its regulatory potential. Many methods of inferring TF activity from gene expression data have been described, but due to the lack of appropriate large-scale datasets, systematic and ob...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189679/ https://www.ncbi.nlm.nih.gov/pubmed/33135076 http://dx.doi.org/10.1093/bioinformatics/btaa947 |