Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors
CAR T cell therapy remains ineffective in solid tumors, due largely to poor infiltration and T cell suppression at the tumor site. T regulatory (T(reg)) cells suppress the immune response via inhibitory factors such as transforming growth factor–β (TGF-β). T(reg) cells expressing the C-C chemokine r...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189699/ https://www.ncbi.nlm.nih.gov/pubmed/34108220 http://dx.doi.org/10.1126/sciadv.abi5781 |