Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

CAR T cell therapy remains ineffective in solid tumors, due largely to poor infiltration and T cell suppression at the tumor site. T regulatory (T(reg)) cells suppress the immune response via inhibitory factors such as transforming growth factor–β (TGF-β). T(reg) cells expressing the C-C chemokine r...

Descripción completa

Detalles Bibliográficos
Autores principales: Cadilha, Bruno L., Benmebarek, Mohamed-Reda, Dorman, Klara, Oner, Arman, Lorenzini, Theo, Obeck, Hannah, Vänttinen, Mira, Di Pilato, Mauro, Pruessmann, Jasper N., Stoiber, Stefan, Huynh, Duc, Märkl, Florian, Seifert, Matthias, Manske, Katrin, Suarez-Gosalvez, Javier, Zeng, Yi, Lesch, Stefanie, Karches, Clara H., Heise, Constanze, Gottschlich, Adrian, Thomas, Moritz, Marr, Carsten, Zhang, Jin, Pandey, Dharmendra, Feuchtinger, Tobias, Subklewe, Marion, Mempel, Thorsten R., Endres, Stefan, Kobold, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189699/
https://www.ncbi.nlm.nih.gov/pubmed/34108220
http://dx.doi.org/10.1126/sciadv.abi5781

Ejemplares similares

Ejemplares similares