Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor

Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer’s disease (AD) and other tauopathies, but it is unclear how neuroanatomical connections, spatial proximity, and regional vulnerability contribute. In this study, we seed tau pathology in the br...

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Detalles Bibliográficos
Autores principales: Cornblath, Eli J., Li, Howard L., Changolkar, Lakshmi, Zhang, Bin, Brown, Hannah J., Gathagan, Ronald J., Olufemi, Modupe F., Trojanowski, John Q., Bassett, Danielle S., Lee, Virginia M. Y., Henderson, Michael X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189700/
https://www.ncbi.nlm.nih.gov/pubmed/34108219
http://dx.doi.org/10.1126/sciadv.abg6677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189700/
https://www.ncbi.nlm.nih.gov/pubmed/34108219
http://dx.doi.org/10.1126/sciadv.abg6677

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