Dynamic properties of SARS-CoV and SARS-CoV-2 RNA-dependent RNA polymerases studied by molecular dynamics simulations

One of the promising drug targets against COVID-19 is an RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. The tertiary structures of the SARS-CoV-2 and SARS-CoV RdRps are almost the same. However, the RNA-synthesizing activity of the SARS-CoV RdRp is higher than that of the SARS-CoV-2 RdRp. We per...

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Detalles Bibliográficos
Autores principales: Itoh, Satoru G., Tanimoto, Shoichi, Okumura, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189741/
https://www.ncbi.nlm.nih.gov/pubmed/34127868
http://dx.doi.org/10.1016/j.cplett.2021.138819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189741/
https://www.ncbi.nlm.nih.gov/pubmed/34127868
http://dx.doi.org/10.1016/j.cplett.2021.138819

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