Cargando…

Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study

BACKGROUND: Insulin is the key regulator of glucose metabolism, but it is difficult to dissect direct insulin from glucose-induced effects. We aimed to investigate the effects of hyperinsulemia on metabolomic measures under euglycemic conditions in nondiabetic participants. METHODS: We assessed conc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Wenyi, van Dijk, Ko Willems, Wijsman, Carolien A., Rozing, Maarten P., Mooijaart, Simon P., Beekman, Marian, Slagboom, P. Eline, Jukema, J. Wouter, Noordam, Raymond, van Heemst, Diana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190027/ https://www.ncbi.nlm.nih.gov/pubmed/34106350 http://dx.doi.org/10.1007/s11306-021-01806-2

Ejemplares similares

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
por: Ayala, Julio E., et al.
Publicado: (2011)

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
por: Mooijaart, Simon P., et al.
Publicado: (2010)

A mathematical model of the euglycemic hyperinsulinemic clamp
por: Picchini, Umberto, et al.
Publicado: (2005)

C-reactive protein and glucose regulation in familial longevity
por: Rozing, Maarten P., et al.
Publicado: (2011)

Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps
por: Tam, Charmaine S., et al.
Publicado: (2012)

Presence of Myeloperoxidase in Lamellar Tissue of Horses Induced by an Euglycemic Hyperinsulinemic Clamp
por: Storms, Nazare, et al.
Publicado: (2022)

Homocysteine and Familial Longevity: The Leiden Longevity Study
por: Wijsman, Carolien A., et al.
Publicado: (2011)

Effect of digital hypothermia on lamellar inflammatory signaling in the euglycemic hyperinsulinemic clamp laminitis model
por: Stokes, Simon M., et al.
Publicado: (2020)

Blood pressure in Warmblood horses before and after a euglycemic-hyperinsulinemic clamp
por: Nostell, Katarina, et al.
Publicado: (2015)

Blood pressure in Warmblood horses before and during a euglycemic-hyperinsulinemic clamp
por: Nostell, Katarina E. A., et al.
Publicado: (2016)

Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test
por: Berhane, Feven, et al.
Publicado: (2015)

Comparison between the euglycemic-hyperinsulinemic clamp and the use of proxies for determination of insulin sensitivity in horses
por: Bröjer, Johan, et al.
Publicado: (2015)

Evaluation of insulin sensitivity by hyperinsulinemic-euglycemic clamps using stable isotope-labeled glucose
por: Zhang, Yuanyuan, et al.
Publicado: (2018)

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes
por: van der Kroef, Sabrina, et al.
Publicado: (2016)

High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes
por: Noordam, Raymond, et al.
Publicado: (2018)

Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
por: Shin, Dongseong, et al.
Publicado: (2019)

The metabolic footprint of compromised insulin sensitivity under fasting and hyperinsulinemic-euglycemic clamp conditions in an Arab population
por: Halama, Anna, et al.
Publicado: (2020)

Prevalence and degree of insulin resistance in Chinese Han women with PCOS: Results from euglycemic‐hyperinsulinemic clamps
por: Li, Weiping, et al.
Publicado: (2018)

Relationships of surrogate indexes of insulin resistance with insulin sensitivity assessed by euglycemic hyperinsulinemic clamp and subclinical vascular damage
por: Fiorentino, Teresa Vanessa, et al.
Publicado: (2019)

Relation of cardiac function to insulin resistance as evaluated by hyperinsulinemic‐euglycemic clamp analysis in individuals with type 2 diabetes
por: Otowa‐Suematsu, Natsu, et al.
Publicado: (2021)

Clinical Pharmacology of Insulin Aspart Biosimilar GP40071: Pharmacokinetic/Pharmacodynamic Comparability in Hyperinsulinemic Euglycemic Clamp Procedure
por: Drai, Roman V., et al.
Publicado: (2022)

Relationship Between β‐cell Response and Insulin Sensitivity in Horses based on the Oral Sugar Test and the Euglycemic Hyperinsulinemic Clamp
por: Lindåse, S., et al.
Publicado: (2017)

Investigation of d-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats
por: Natsume, Yukie, et al.
Publicado: (2021)

The Effects of Acute High‐Intensity Interval Exercise and Hyperinsulinemic‐Euglycemic Clamp on Osteoglycin Levels in Young and Middle‐Aged Men
por: Bauer, Carlie, et al.
Publicado: (2022)

The association of measures of body shape and adiposity with incidence of cardiometabolic disease from an ageing perspective
por: Meulmeester, Fleur L., et al.
Publicado: (2022)

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age
por: Noordam, Raymond, et al.
Publicado: (2016)

Intraocular pressure and aqueous humor flow during a euglycemic-hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications
por: Lane, James T, et al.
Publicado: (2010)

Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus
por: Mori, Katsuhito, et al.
Publicado: (2012)

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease
por: Surowiec, Izabella, et al.
Publicado: (2019)

Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity
por: Bos, Maxime M., et al.
Publicado: (2020)

Comment on: Tam et al. Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps. Diabetes Care 2012;35:1605–1610
por: Færch, Kristine, et al.
Publicado: (2013)

Comment on: Tam et al. Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps. Diabetes Care 2012;35:1605–1610
por: Davidson, Mayer B.
Publicado: (2013)

Diet‐Derived Antioxidants Do Not Decrease Risk of Ischemic Stroke: A Mendelian Randomization Study in 1 Million People
por: Martens, Leon G., et al.
Publicado: (2021)

Response to Comment on: Tam et al. Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps. Diabetes Care 2012;35:1605–1610
por: Tam, Charmaine S., et al.
Publicado: (2013)

Human insulin/IGF-1 and familial longevity at middle age
por: Rozing, Maarten P., et al.
Publicado: (2009)

The GLP-1 Analogue Exenatide Improves Hepatic and Muscle Insulin Sensitivity in Diabetic Rats: Tracer Studies in the Basal State and during Hyperinsulinemic-Euglycemic Clamp
por: Wu, Hui, et al.
Publicado: (2014)

Glycaemia influences glucose metabolism in sepsis during hyperinsulinemic clamp
por: Rušavý, Z, et al.
Publicado: (1998)

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus
por: Noordam, Raymond, et al.
Publicado: (2017)

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
por: van der Spoel, Evie, et al.
Publicado: (2015)

Effects of a Web-Based Intervention on Physical Activity and Metabolism in Older Adults: Randomized Controlled Trial
por: Wijsman, Carolien A, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_k7m7s7k2fj6ot0vi3othq5pmp7