Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells

Age-related morbidity is associated with a decline in hematopoietic stem cell (HSC) function, but the mechanisms of HSC aging remain unclear. We performed heterochronic HSC transplants followed by quantitative analysis of cell reconstitution. Although young HSCs outperformed old HSCs in young recipi...

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Detalles Bibliográficos
Autores principales: Poscablo, Donna M., Worthington, Atesh K., Smith-Berdan, Stephanie, Forsberg, E. Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190594/
https://www.ncbi.nlm.nih.gov/pubmed/34019813
http://dx.doi.org/10.1016/j.stemcr.2021.04.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190594/
https://www.ncbi.nlm.nih.gov/pubmed/34019813
http://dx.doi.org/10.1016/j.stemcr.2021.04.016

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