Cargando…

Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells

Age-related morbidity is associated with a decline in hematopoietic stem cell (HSC) function, but the mechanisms of HSC aging remain unclear. We performed heterochronic HSC transplants followed by quantitative analysis of cell reconstitution. Although young HSCs outperformed old HSCs in young recipi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poscablo, Donna M., Worthington, Atesh K., Smith-Berdan, Stephanie, Forsberg, E. Camilla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190594/ https://www.ncbi.nlm.nih.gov/pubmed/34019813 http://dx.doi.org/10.1016/j.stemcr.2021.04.016

Ejemplares similares

IL7Rα, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells
por: Worthington, Atesh K., et al.
Publicado: (2022)

The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions
por: Poscablo, Donna M., et al.
Publicado: (2021)

A CRISPR view of hematopoietic stem cells: Moving innovative bioengineering into the clinic
por: Worthington, Atesh K., et al.
Publicado: (2022)

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells
por: Cova, Giovanni, et al.
Publicado: (2021)

Distal lung epithelial progenitor cell function declines with age
por: Watson, Julie K., et al.
Publicado: (2020)

Ricolinostat promotes the generation of megakaryocyte progenitors from human hematopoietic stem and progenitor cells
por: Jiang, Jianan, et al.
Publicado: (2022)

Megakaryocytes Are Regulators of the Tumor Microenvironment and Malignant Hematopoietic Progenitor Cells in Myelofibrosis
por: Varricchio, Lilian, et al.
Publicado: (2022)

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias
por: Rundberg Nilsson, Alexandra, et al.
Publicado: (2016)

Age-related decline in LEPR(+) hematopoietic stem cell function
por: Trinh, Thao, et al.
Publicado: (2023)

Megakaryocyte membrane‐wrapped nanoparticles for targeted cargo delivery to hematopoietic stem and progenitor cells
por: Das, Samik, et al.
Publicado: (2022)

Viagra Enables Efficient, Single-Day Hematopoietic Stem Cell Mobilization
por: Smith-Berdan, Stephanie, et al.
Publicado: (2019)

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
por: Chambers, Stuart M, et al.
Publicado: (2007)

Engineering human megakaryocytic microparticles for targeted delivery of nucleic acids to hematopoietic stem and progenitor cells
por: Kao, Chen-Yuan, et al.
Publicado: (2018)

ROBO4-Mediated Vascular Integrity Regulates the Directionality of Hematopoietic Stem Cell Trafficking
por: Smith-Berdan, Stephanie, et al.
Publicado: (2015)

Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation
por: Liu, Ailing, et al.
Publicado: (2018)

Infusion of Megakaryocytic Progenitor Products Generated from Cord Blood Hematopoietic Stem/Progenitor Cells: Results of the Phase 1 Study
por: Xi, Jiafei, et al.
Publicado: (2013)

Establishment of an ES Cell-Derived Murine Megakaryocytic Cell Line, MKD1, with Features of Primary Megakaryocyte Progenitors
por: Chagraoui, Hedia, et al.
Publicado: (2012)

Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice
por: So, Eui-Young, et al.
Publicado: (2020)

Glucose Metabolism and Aging of Hematopoietic Stem and Progenitor Cells
por: Poisa-Beiro, Laura, et al.
Publicado: (2022)

Megakaryocytes promote osteoclastogenesis in aging
por: Kanagasabapathy, Deepa, et al.
Publicado: (2020)

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
por: Psaila, Bethan, et al.
Publicado: (2016)

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment
por: Kirschner, Kristina, et al.
Publicado: (2017)

Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche
por: Zhan, Huichun, et al.
Publicado: (2022)

Acute and endothelial-specific Robo4 deletion affect hematopoietic stem cell trafficking independent of VCAM1
por: Smith-Berdan, Stephanie, et al.
Publicado: (2021)

Megakaryocyte Diversity in Ontogeny, Functions and Cell-Cell Interactions
por: Khatib-Massalha, Eman, et al.
Publicado: (2022)

Two Ellagic Acids Isolated from Roots of Sanguisorba officinalis L. Promote Hematopoietic Progenitor Cell Proliferation and Megakaryocyte Differentiation
por: Gao, Xiaoping, et al.
Publicado: (2014)

Developmental cues license megakaryocyte priming in murine hematopoietic stem cells
por: Kristiansen, Trine A., et al.
Publicado: (2022)

Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche
por: Li, Yinghui, et al.
Publicado: (2023)

Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice
por: Frobel, Joana, et al.
Publicado: (2018)

Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during aging
por: Abdelfattah, Ali, et al.
Publicado: (2021)

P1348: C3G CONTROLS MEGAKARYOCYTE INFLUENCE ON MYELOID COMMITMENT OF HEMATOPOIETIC STEM CELLS UPON CHEMOTHERAPY-INDUCED MYELOSUPPRESSION.
por: Herranz, Óscar, et al.
Publicado: (2023)

Age-associated declining of the regeneration potential of skeletal stem/progenitor cells
por: Mancinelli, Luigi, et al.
Publicado: (2023)

The Reconstitution Dynamics of Cultivated Hematopoietic Stem Cells and Progenitors Is Independent of Age
por: Gotzhein, Frauke, et al.
Publicado: (2022)

P1397: CHRONICALLY REDUCED LEVELS OF THROMBOPOIETIN IMPAIR HEMATOPOIETIC STEM CELL FUNCTION AND MEGAKARYOCYTE BONE MARROW NICHE
por: Aprile, A., et al.
Publicado: (2022)

Downregulation of an Aim-1 Kinase Couples with Megakaryocytic Polyploidization of Human Hematopoietic Cells
por: Kawasaki, Akira, et al.
Publicado: (2001)

Megakaryocytes regulate hematopoietic stem cell quiescence via Cxcl4 secretion
por: Bruns, Ingmar, et al.
Publicado: (2014)

CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow
por: Nakamura-Ishizu, Ayako, et al.
Publicado: (2015)

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging
por: Rübe, Claudia E., et al.
Publicado: (2011)

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging
por: Young, Kira, et al.
Publicado: (2016)

Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells
por: Poisa-Beiro, Laura, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ek9khg78sq6jbg7af1je1s0fvr