Exact mapping of Illumina blind spots in the Mycobacterium tuberculosis genome reveals platform-wide and workflow-specific biases

Whole-genome sequencing (WGS) is fundamental to Mycobacterium tuberculosis basic research and many clinical applications. Coverage across Illumina-sequenced M. tuberculosis genomes is known to vary with sequence context, but this bias is poorly characterized. Here, through a novel application of phy...

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Detalles Bibliográficos
Autores principales: Modlin, Samuel J., Robinhold, Cassidy, Morrissey, Christopher, Mitchell, Scott N., Ramirez-Busby, Sarah M., Shmaya, Tal, Valafar, Faramarz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190613/
https://www.ncbi.nlm.nih.gov/pubmed/33502304
http://dx.doi.org/10.1099/mgen.0.000465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190613/
https://www.ncbi.nlm.nih.gov/pubmed/33502304
http://dx.doi.org/10.1099/mgen.0.000465

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