Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

With the discovery of PROteolysis TArgeting Chimeras (PROTACs) twenty years ago, targeted protein degradation (TPD) has changed the landscape of drug development. PROTACs have evolved from cell-impermeable peptide-small molecule chimeras to orally bioavailable clinical candidate drugs that degrade o...

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Detalles Bibliográficos
Autores principales: Bond, Michael J., Crews, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190915/
https://www.ncbi.nlm.nih.gov/pubmed/34212149
http://dx.doi.org/10.1039/d1cb00011j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190915/
https://www.ncbi.nlm.nih.gov/pubmed/34212149
http://dx.doi.org/10.1039/d1cb00011j

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