Genotype-determined EGFR-RTK heterodimerization and its effects on drug resistance in lung Cancer treatment revealed by molecular dynamics simulations

BACKGROUND: Epidermal growth factor receptor (EGFR) and its signaling pathways play a vital role in pathogenesis of lung cancer. By disturbing EGFR signaling, mutations of EGFR may lead to progression of cancer or the emergence of resistance to EGFR-targeted drugs. RESULTS: We investigated the corre...

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Detalles Bibliográficos
Autores principales: Zhu, Mengxu, Wang, Debby D., Yan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191231/
https://www.ncbi.nlm.nih.gov/pubmed/34112110
http://dx.doi.org/10.1186/s12860-021-00358-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191231/
https://www.ncbi.nlm.nih.gov/pubmed/34112110
http://dx.doi.org/10.1186/s12860-021-00358-6

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