The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1

Insulin-like growth factor (IGF) is a potent mitogen that activates the IGF receptor (IGFR)/insulin receptor substrate (IRS) axis, thus stimulating growth in normal cells and uncontrolled cell proliferation in cancer. Posttranslational modifications of IRS such as ubiquitination tightly control IGF...

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Detalles Bibliográficos
Autores principales: Yu, Wenjuan, Singh, Ramesh, Wang, Zhao, O’Malley, Bert W., Yi, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191236/
https://www.ncbi.nlm.nih.gov/pubmed/33991522
http://dx.doi.org/10.1016/j.jbc.2021.100739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191236/
https://www.ncbi.nlm.nih.gov/pubmed/33991522
http://dx.doi.org/10.1016/j.jbc.2021.100739

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