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Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly

Marburg virus (MARV) is a lipid-enveloped virus harboring a negative-sense RNA genome, which has caused sporadic outbreaks of viral hemorrhagic fever in sub-Saharan Africa. MARV assembles and buds from the host cell plasma membrane where MARV matrix protein (mVP40) dimers associate with anionic lipi...

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Detalles Bibliográficos
Autores principales: Amiar, Souad, Husby, Monica L., Wijesinghe, Kaveesha J., Angel, Stephanie, Bhattarai, Nisha, Gerstman, Bernard S., Chapagain, Prem P., Li, Sheng, Stahelin, Robert V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191294/
https://www.ncbi.nlm.nih.gov/pubmed/34019871
http://dx.doi.org/10.1016/j.jbc.2021.100796